Question
A 25 year old male is diagnosed to have the condition as represented in the x-ray below involving his right femur. Mutation of which of the following gene can be related to the development of the condition ?
A. APC gene.
B. Bcl 2 gene.
C. RB gene.
D. C myc gene.
Show Answer
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Correct Answer » C
Explanation
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Patient is suffering from osteosarcoma.
Mutation of the Rb gene can result in retinoblastoma, osteosarcoma, breast cancer and small cell carcinoma.
Mutation of APC gene is found in 70-80% of non familial colon carcinomas, 50% of hepatoblastomas and 20% of hepatocellular carcinomas.
Mutation of Bcl 2 gene is associated with the development of follicular lymphoma.
C myc gene is associated with Burkitt’s lymphoma
Mutation of p53 gene is found in more than 70% of tumors.
Mutation of NF1 gene is associated with the development of neurofibromas and malignant peripheral nerve sheath tumors.
Mutation of VHL gene is associated with nonfamilial renal cell carcinomas.
