ANTI-SMOKING DRUGS
ANTI-SMOKING DRUGS
| Anti-smoking drug | Drug category | Description & drug details |
|
Varenicline
|
Direct acting nicotinic agonist |
|
|
Nicotine patch
|
A transdermal patch
|
|
|
Bupropion/Amfebutamone
|
Anti-depressant drug
& nicotinic receptor antagonist |
|
| Clonidine | Centrally acting alpha-agonist |
|
| Rimonabant | Cannabinoid receptor antagonist |
|
| Topiramate | Antagonist at AMPA/kainate receptors of glutamate |
|
| Nortryptyline | Main active metabolite of amitriptyline. |
|
| Glucose |
|
|
| Mecamylamine | Nicotine antagonist |
|
|
Tryptophan
& high carbohydrate diet |
Serotonin enhancing substances |
|
Exam Important
ANTI-SMOKING DRUGS
- Nicotine replacement therapy is available in all forms like chewing gum, lozenges, patch, except tablets.
- Bupropion (along with Varenicline & Nicotine replacement therapy) is a USFDA approved first-line agent for pharmacotherapy in smoking cessation.
- Nicotine replacement therapy includes transdermal patch, gum, lozenges, oral inhaler & nasal spray.
- Varenicline is a selective partial agonist at Alpha4-Beta2 Nicotinic A-Choline receptor, that is believed to mediate nicotine dependence.
- Bupropion is a nicotinic receptor antagonist.
- Bupropion/amfebutamone is used both for atypical antidepressant & smoking cessation aid.
- Bupropion acts as a norepinephrine & dopamine reuptake inhibitor (NDRI), and alpha3 beta4-nicotinic receptor antagonist.
- Bupropion is used in prophylaxis of nicotine addiction.
- Bupropion/Amfebutamone decreases nicotine craving.
- Bupropion/Amfebutamone shows increased efficacy when combined with nicotine patch.
- Mecamylamine is a nicotine antagonist, used as an anti-smoking drug.
- Nortryptyline is an active metabolite of amitriptyline, used as an anti-smoking drug.
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