Which app has NEET PG PYQs from 2012 to 2025?

MedicoApps provides authentic NEET PG previous year questions from 2012 to 2025 with detailed explanations, clinical coverage, and offline access.

How many questions are included in MedicoApps?

MedicoApps includes over 10,000 meticulously crafted clinical and image-based questions, each with a detailed explanation covering NEET PG, NeXT PG, INI CET, and FMGE exams.

Does the MedicoApps NEET PG app support offline access?

Yes, MedicoApps is fully offline. You can study and practice previous year questions without an internet connection.

Does MedicoApps include clinical and image-based questions?

Yes, MedicoApps includes clinical and image-based questions with complete explanations and references, covering subjects tested in NEET PG.

Does MedicoApps focus on repeated concepts and high-yield topics?

Yes, MedicoApps follows an 80/20 high-yield preparation approach, emphasising repeated concepts since 60-75% of NEET PG questions come from concepts tested in past exams.

Is there an update frequency for new questions in MedicoApps?

The app is regularly updated to align with the latest NEET PG exam patterns and includes new questions as per evolving trends in medical entrance exams.

Do the questions in MedicoApps come with detailed explanations?

Yes, each question is accompanied by an explanatory note that clarifies the concept behind the answer and references relevant sources.

Which previous year exams are included in MedicoApps?

MedicoApps includes authentic previous year questions from NEET PG, NeXT PG, INI CET, and FMGE exams, spanning from 2012 to 2025.

Is MedicoApps suitable for students at different stages of NEET PG preparation?

Yes, MedicoApps is suitable for both beginners and advanced students. It offers a wide range of questions to support preparation at all stages.

Is there a money-back guarantee for MedicoApps?

Yes, MedicoApps offers a no-questions-asked 30-day money-back guarantee on all premium plans.

What is the best QBank for NEET PG?

A good NEET PG QBank should include PYQs, clinical MCQs, image-based questions, and grand tests. MedicoApps provides all these features along with offline access and explanations in one platform.

Where can I practice NEET PG previous year questions?

You can practice NEET PG previous year questions on MedicoApps, which includes 10,000+ questions from 2012 to 2025 with detailed explanations and offline support.

How can I contact MedicoApps support?

You can reach the MedicoApps customer support team through the app or the official website at medicoapps.org.

ANTI-TOXICITY DRUGS USED IN CANCER THERAPY

ANTI-TOXICITY DRUGS USED IN CANCER THERAPY

TOXICITIES OF ANTI-CANCER DRUGS:

1. Toxicities of alkylating agents:

All alkylating agents are myelosuppressive, pulmonary fibrosis, sterility & secondary leukemias (less common with cyclophosphamide).
In high dose, all alkylating agents cause veno-occlusive disease in liver (reversed by defibrotide).

Alkylating agents	Distinctive toxicity
Cyclophosphamide	Alopecia, hemorrhagic cystitis, SIADH
Nitrosoureas & ifosfamide	Renal failure
Nitrosoureas & mechlorethamine	Local irritation & damage – Due to strong vesicant properties
Ifosfamide	Hemorrhagic cystitis, SIADH
Busulfan	Pulmonary fibrosis, hyperpigmentation, adrenal insufficiency
Procarbazine	Secondary leukemia, disulfiram-like-reaction, behavioral changes, CNS depression
Cisplatin	Emesis, nephrotoxicity, peripheral sensory neuropathy, ototoxicity

2. Toxicities of anti-metabolites:

All antineoplastic antimetabolites cause bone marrow suppression

Anti-metabolites	Distinctive toxicity
6-MP & 6-TG	Hepatotoxicity
Methotrexate	Mucositis, hepatotoxicity
5-FU	Hand and foot syndrome, neurotoxicity
Capecitabine	Hand and foot syndrome, Hyperbilirubinemia
Cytarabine	Cerebellar ataxia
Fludarabine	Arthralgia
Gemcitabine	Diarrhea

3. Toxicities of natural anticancer drugs:

All natural anticancer products can cause bone marrow suppression except bleomycin & vincristine.

Natural anticancer drugs	Distinctive toxicity
Bleomycin	Pulmonary fibrosis (Marrow sparing)
Anthracyclines	Cardiotoxicity
Paclitaxel	Peripheral neuropathy & hypersensitivity
Docetaxel	Peripheral neuropathy, Fluid retention
Irinotecan	Diarrhea
Vincristine	Peripheral neuropathy (Marrow sparing), SIADH.

4. Toxicities of hormonal agents:

Hormonal agents	Distinctive toxicity
Flutamide	Hot flushes, liver dysfunction
SERMs	Menopausal symptoms, fluid retention, thromboembolism, increased incidence of endometrial cancer
Progestins	Fluid retention
Corticosteroids	Fluid retention, hypertension, diabetes, increased susceptibility to infections
GnRH agonists	Transient flare-up reaction, hot flushes, impotence, gynecomastia, osteoporosis
Aminoglutethimide	Adrenal insufficiency, myelosuppression, rash
Aromatase inhibitors	Fatigue, hot flushes, arthralgia

TREATMENT:

Anti-toxicity drugs for anti-cancer drugs:

Anti-toxicity drug	Mechanism	Indications
Allopurinol	Inhibit xanthine oxidase	Prevent hyperuricemia from tumor lysis syndrome
Rasburicase	Recombinant urate oxidase	Prevent hyperuricemia from tumor lysis
Mesna (Sodium 2-mercapto ethane sulfonate)	Neutralizing agent	Prevent hemorrhagic cystitis (due to ifosfamide) with high dose cyclophosphamide.
Leucovorin	Replete tetrahydrofolic acid	Rescue after high dose methotrexate
Amifostine		Prevent radiation-induced xerostomia & Cisplatin-induced nephrotoxicity.
Dexrazoxane	Iron-chelator	Prevent cardiotoxicity due to anthracyclines
Palifermin	Keratinocyte growth factor	Prevent mucositis following chemotherapy
Pilocarpine	Cholinergic agonist	Radiation-induced xerostomia
Pamidronate & Zolendronate	Bisphosphonates	Hypercalcemia of malignancy
Epoetin-alpha & Darbopoetin-alpha	Erythropoietin	Anemia
Filgrastim & PegFilgrastim Sargramostim	G-CSF & GM-CSF respectively	Febrile neutropenia prophylaxis
Oprelvekin	IL-11	Thrombocytopenia
Ondansetron, Granisetron & Palonosetron	Ondansetron – 5-HT antagonist Granisetron & Palonosetron – 5HT3 antagonist	Nausea & vomiting
Aprepitant & Fosaprepitant	NK-1 antagonist	Cisplatin-induced delayed vomiting

Exam Important

Drugs used to prevent toxicity of anti-cancer drugs include allopurinol, rasburicase, mesna, leucovorin, amifostine, dexrazoxane, palifermin, pilocarpine, pamidronate, filgrastim, sargramostim, ondansetron, granisetron, aprepitant& fosaprepitant.
Anticancer drugs having highest emetogenic potential is cisplatin.
Antineoplastic agent is an antifolate drug is Methotrexate.
Aprepitant & Fosaprepitant are NK-1 antagonists used for cisplatin-induced delayed vomiting.
Ondansetron is a 5-HT antagonist useful for treating vomiting.
Granisetron & Palonosetron are 5HT3 antagonist.
Sargramostim is a GM-CSF used for treating anti-cancer drug-induced neutropenia.
Pamidronate is
Mesna is sodium 2-mercapto ethane sulfonate, is useful for preventing hemorrhagic cystitis (due to ifosfamide).
Vincristine causes peripheral neuropathy & SIADH.
Anticancer drug bleomycin causes pulmonary fibrosis.
5-FU is an anticancer drug result in hand & foot syndrome.
Cisplatin is responsible for emesis & nephrotoxicity.
Procarbazine produces disulfiram-like-reaction.
Busulfan can result in pulmonary fibrosis.
Cyclophosphamide can cause hemorrhagic cystitis.

Don’t Forget to Solve all the previous Year Question asked on ANTI-TOXICITY DRUGS USED IN CANCER THERAPY
Click Here to Start Quiz

ANTI-TOXICITY DRUGS USED IN CANCER THERAPY