Antiphospholipid antibody syndrome-Diagnosis

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Antiphospholipid antibody syndrome-Diagnosis

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Clinical diagnosis:
1. Arterial/ Venous Thrombosis (Superficial/Deep)

1. ≥3 losses in <10 weeks 3. ≥1 loss in >10 weeks of morphologically normal fetus.

2. At least 1 Preterm delivery secondary to severe PIH/Uteroplacental insufficiency

Lab Findings:

1. Presence of Lupus Anticoagulant (LAC)

2. Presence of IgM / IgG Cardiolipin Antibody Any of these should beresent@2occasions12wksapart

3. Presence of β2 Micro globulin

Note: In APLA – APTT is prolonged; PT is normal; Russel viper venom time is prolonged.