Antiphospholipid antibody syndrome-Diagnosis


Antiphospholipid antibody syndrome-Diagnosis


Clinical diagnosis:
1. Arterial/ Venous Thrombosis (Superficial/Deep)

  1. ≥3 losses in <10 weeks 3. ≥1 loss in >10 weeks of morphologically normal fetus.

  2. At least 1 Preterm delivery secondary to severe PIH/Uteroplacental insufficiency

Lab Findings:

  1. Presence of Lupus Anticoagulant (LAC)

  2. Presence of IgM / IgG Cardiolipin Antibody Any of these should beresent@2occasions12wksapart

  3. Presence of β2 Micro globulin

Note: In APLA – APTT is prolonged; PT is normal; Russel viper venom time is prolonged.

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