Biosynthesis of Heme
BIOSYNTHESIS OF HEME
- Heme is synthesized in all cells but mainly in bone marrow and liver.
- Organelle- cytoplasm and mitochondria

- Synthesis of ALA occurs in mitochondria (Rate limiting step)
- Synthesis of porphobilinogen, hydroxymethylbilane, uroporphyrinogen, coproporpyrinogen- occurs in cytosol.
- Synthesis of protporphyrinogen occurs in mitochondria
- Formation of heme occurs in mitochondria.
Exam Important
- Heme is synthesized in all cells but mainly in bone marrow and liver.
- Organelle- cytoplasm and mitochondri
- Synthesis of ALA occurs in mitochondria (Rate limiting step)
- Synthesis of porphobilinogen, hydroxymethylbilane, uroporphyrinogen, coproporpyrinogen- occurs in cytosol.
- Synthesis of protporphyrinogen occurs in mitochondria
- Formation of heme occurs in mitochondria.
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