Biosynthesis of Heme

Biosynthesis of Heme


BIOSYNTHESIS OF HEME

  • Heme is synthesized in all cells but mainly in bone marrow and liver.
  • Organelle- cytoplasm and mitochondria
  • Synthesis of ALA occurs in mitochondria (Rate limiting step)
  • Synthesis of porphobilinogen, hydroxymethylbilane, uroporphyrinogen, coproporpyrinogen- occurs in cytosol.
  • Synthesis of protporphyrinogen occurs in mitochondria
  • Formation of heme occurs in mitochondria.

Exam Important

  • Heme is synthesized in all cells but mainly in bone marrow and liver.
  • Organelle- cytoplasm and mitochondri
  • Synthesis of ALA occurs in mitochondria (Rate limiting step)
  • Synthesis of porphobilinogen, hydroxymethylbilane, uroporphyrinogen, coproporpyrinogen- occurs in cytosol.
  • Synthesis of protporphyrinogen occurs in mitochondria
  • Formation of heme occurs in mitochondria.
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