CHLOROMA

• Also called as myeloblastoma, granulocytic sarcoma.
• It is a localised tumour forming mass occurring in the skin of orbital & periorbital tissue due to infiltration of tissues by leukemic cells.
• It is hematopoietic stem cell tumour.
• Most commonly associated with t (8: 21) & AML M2.

Etiology-

• Myelodysplastic syndrome (MDS)
• Myeloproliferative syndrome (MPS)

Pathogenesis-

• Arbiskov cells are monocytes seen in myeloblastoma.

Clinical features-

• Most commonly involved areas are skin & gums, orbit of eyes.
• Gum hypertrophy

 

Diagnosis-

• Biopsy

Treatment–

• Chemotherapy
• Surgery
• Radiation therapy

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