CHOLECYSTOKININ (CCK)

CHOLECYSTOKININ (CCK)/Cholecystokinin-Pancreozymin (CCK-PZ)

• Secreted by cells in upper intestinal mucosa 

– I cells in small intestine (Duodenum, jejunum & ileum)

• Also in nerves in distal ileum & colon 

• Neurons in brain & other parts of body.

Stimulus for secretion:

• Products of protein digestion i.e., amino acids & peptides

• Presence of long chain fatty acids  (>10 carbon atoms) in duodenum.

– Not triglycerides.

– Digestible form of fat.

– Carbohydrates are ineffective

FUNCTIONS:

• Stimulates pancreatic acinar cell enzymes secretion.

• Causes contraction of gall bladder.

• Relaxation of sphincter of oddi.

• Secretion of enzyme-rich pancreatic juice.

• Potentiates action of secretin on pancreas.

• Inhibits gastric emptying

• Increases motility of small intestine & colon.

• Increases enterokinase secretion

Produces satiety 

• Mechanism for hunger suppression is thought to be a decrease in gastric emptying rate.

• Relaxes lower esophageal sphincter secretin

• Augments contraction of pyloric sphincter

• Prevents reflux of duodenal contents into stomach

• Exerts trophic effect on pancreases

• Stimulates both insulin & glucagon secretion.

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