Coccidioides immitis
Coccidioides immitis
- It is a dimorphic fungus with septate hyphae.
- Fungus causing endemic mycosis -Coccidioidomycosis
Has two forms.
- White fluffy mould on most culture media(Sabouraund’s agar)
- Nonbudding spherical form-a spherule, in host tissue.
- C. immitis reproduces in host tissue by forming small endospores within mature spherules.
- Fungus is identified by its appearance by the formation of thick-walled barrel shaped spores, called arthrospores.
Transmission
- Infection is acquired by dust containing arthrospores.
Clinical manifestations
- Most of the infections are asymptomatic Asymptomatic pulmonary nodule.
- Many persons develop a self limited influenza like fever —> Valley fever or desert rheumatism. – Acute pneumonia
- Chronic fibrocavitatory pneumonia
- Chronic dissemination:
- Bone
- Meninges
- Skin
- Joints Subcutaneous tissue
Treatment
- Most Coccidioides infections have an incubation period from one to four weeks
- Resolve without specific therapy.
Exam Important
Coccidioides immitis
- It is a dimorphic fungus with septate hyphae.
- Fungus causing endemic mycosis -Coccidioidomycosis
Has two forms.
- White fluffy mould on most culture media(Sabouraund’s agar)
- Nonbudding spherical form-a spherule, in host tissue.
- C. immitis reproduces in host tissue by forming small endospores within mature spherules.
- Fungus is identified by its appearance by the formation of thick-walled barrel shaped spores, called arthrospores.
Clinical manifestations
- Most of the infections are asymptomatic Asymptomatic pulmonary nodule.
- Many persons develop a self limited influenza like fever —> Valley fever or desert rheumatism. – Acute pneumonia
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