Conn’s syndrome

Conn’s syndrome


CONN’S SYNDROME

  • Conn’s syndrome or primary hyperaldosteronism is by hypertension due to hypersecretion of aldosterone.

 Etiology-

  • PHA with hypokalemia is unilateral adrenocortical adenoma (most frequent).

Clinical features-

  • Females are more affected.
  • Seen between 30- 50 years of age.
  • Hypertension , hypokalemic alkalosis, hypernatremia
  • Headache
  • Muscle weakness (proximal myopathy), cramps.
  • Neurological events.
  • Polyuria, polydyspsia and nocturia
  • Diastolic hypertension without oedema.
 

 Investigations-

  • Assessment of aldosterone to plasma rennin activity (ARR ratio)
  • Conn’s adenomas are detected mostly

Treatment-

  • Bilateral hyperplasma- spironolactone
  • Antihypertensive drugs
  • Unilateral laproscopic adrenolectomy
  • Subtotal adrenal resection- Single Conn’s adenoma.

Exam Important

  • Conn’s syndrome or primary hyperaldosteronism is by hypertension due to hypersecretion of aldosterone.

 Etiology-

  • PHA with hypokalemia is unilateral adrenocortical adenoma (most frequent).

Clinical features-

  • Females are more affected.
  • Seen between 30- 50 years of age.
  • Hypertension , hypokalemic alkalosis, hypernatremia
  • Headache
  • Muscle weakness (proximal myopathy), cramps.
  • Neurological events.
  • Polyuria, polydyspsia and nocturia
  • Diastolic hypertension without oedema.

 Investigations-

  • Assessment of aldosterone to plasma rennin activity (ARR ratio)
  • Conn’s adenomas are detected mostly

Treatment-

  • Bilateral hyperplasma- spironolactone
  • Antihypertensive drugs
  • Unilateral laproscopic adrenolectomy
  • Subtotal adrenal resection- Single Conn’s adenoma.
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