DAPSONE
DAPSONE
- Leprostatic drug.
- Acedapsone – Repository form of dapsone.
- Single IM injection maintains inhibitory levels of dapsone in tissues for up to 3 months.
MECHANISM OF ACTIONS:
PHARMACOKINETICS:
- Dose of Dapsone –
- 1-2 mg/kg
- Absorption: Completely absorbed after oral administration.
- Distribution:
- Approximately 70% bound to plasma protein.
- main metabolite, monoacetyl dapsone, is nearly 100% protein bound.
- Metabolism:
- Acetylated in liver.
- Variable plasma t1/2, mostly
- Elimination takes 1-2 weeks or longer
- Metabolites excreted in bile & urine
USES:
- Dermatitis Herpetiformis – Drug of choice.
- Mycobacterium leprae infections (leprosy)/hansen’s disease.
- WHO regime for paucibacillary leprosy is 100 mg Dapsone daily + Rifampicin monthly (600 mg)
- Acne.
- Pneumocystis pneumonia.
- Alternative drug for Pneumocystis treatment jirooeci infection in AIDS patients.
- Generalised lichen planus
- Toxoplasmosis – Prophylaxis
ADVERSE ACTION:
- Haemolytic anaemia – Most common.
- Gastric intolerance-nausea & anorexia, headache, paresthesias, mental symptoms & drug fever.
- Allergic rashes, fixed drug eruption, hypermelanosis, phototoxicity & rarely exfoliative dermatitis.
- Hepatitis & agranulocytosis.
- DDS syndrome/Dapsone reaction/Sulfone syndrome.
- Causes gastrointestinal irritation fever, skin rash, methemoglobinemia & hemolysis particularly in G-6-PD defrcint patients
DRUG INTERACTIONS:
- Folic acid antagonists (such as pyrimethamine), nitrofurantoin, primaquine.
- This medication may decrease the effectiveness of combination-type birth control pills.
Exam Important
- Dapsone is used in treatment & therapeutic diagnosis of dermatitis herpetiformis.
- Both Dapsone & Systemic steroids drugs are used in generalised lichen planus.
- Rifampicin, dapsone and clofazimine are used if HIV infected patient develops multibacillary leprosy.
- Hemolytic anaemia is the commonest side effect of Dapsone.
- Dose of Dapsone is 1-2 mg/kg.
- WHO regime for paucibacillary leprosy is 100 mg Dapsone daily + Rifampicin monthly (600 mg).
- Fixed drug eruption (FDE) is an adverse cutaneous reaction to an ingested dapsone.
Don’t Forget to Solve all the previous Year Question asked on DAPSONE
Click Here to Start Quiz
Click Here to Start Quiz
