Differential diagnosis of leucocoria


Differential diagnosis of leucocoria


1. Retinoblastoma

2. Congenital Cataract

3. Persistent Hyperplastic primary vitreous [PHPV]

  • Most difficult to d/d from Retinoblastoma

FATES OF VITREOUS:

Before Birth After Birth
•         Primary Vitreous → Disappears (retention → PHPV)
•         Secondary Vitreous → Normal
•         Tertiary Vitreous → Zonules

D/D of PHPV from RB:

PHPV:

  • Always U/L
  • Only seen in small eye (microphthalmos)

4. Coat’s Disease

  • Boys
  • 1st decade of life (7-8 yrs.)

5. ROP

6. Toxocariasis

7. Endophthalmitis

8. Retinal Detachment

9. Norrie’s disease

10. Coloboma

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