Heme Catabolism
HEME CATABOLISM
- Daily bilirubin formation in humans is approx 250-350mg.
- 1gm of haemoglobin yields 35mg of bilirubin.
- Site- reticuloendothelial cells of liver, spleen and bone marrow.
- Hemo oxygenase is green pigment, biliverdin is produced.
- Hemo oxygenase is the only source of endogenous CO in the body.
- Biliverdin Reductase (yellow) takes place in the cytosol.
TRANSPORT OF BILIRUBIN
- Bilirubin is transported to liver bound to serum albumin.
- Bilirubin is transferred to hepatocytes where it is bound to ligandin.
Exam Important
- Daily bilirubin formation in humans is approx 250-350mg.
- 1gm of haemoglobin yields 35mg of bilirubin.
- Site- reticuloendothelial cells of liver, spleen and bone marrow.
- Hemo oxygenase is green pigment, biliverdin is produced.
- Hemo oxygenase is the only source of endogenous CO in the body.
- Biliverdin Reductase (yellow) takes place in the cytosol.
- Bilirubin is transported to liver bound to serum albumin.
- Bilirubin is transferred to hepatocytes where it is bound to ligandin.
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