IMMUNOSTIMULANTS
| A | Has greater oral bioavailability | |
| B | Is more likely to cause thrombocytopenia | |
| C | Is more likely to elicit an allergic reaction | |
| D | Stimulates production of a wider variety of hematopoietic stem cells |
| A | Has greater oral bioavailability | |
| B | Is more likely to cause thrombocytopenia | |
| C | Is more likely to elicit an allergic reaction | |
| D | Stimulates production of a wider variety of hematopoietic stem cells |
Stimulates production of a wider variety of hematopoietic stem cells
GM-CSF has wider biologic activity than G-CSF; it stimulates early myeloid stem cells in addition to cells destined become neutrophils.
Imiquimod is administered by which route:
| A |
Topical |
|
| B |
Inhalation |
|
| C |
Intranasal |
|
| D |
None of the above |
Levamisole is used as all except –
| A |
Single dose in ascariasis |
|
| B |
Immunostimulant |
|
| C |
Paralysis of worms by depolarisation |
|
| D |
Immunodepressant in high doses |
Ans. is ‘d’ i.e., Immunodepressant in high doses
Levamisol
o Levamisole is an immunomodulator – restores depressed T cell function -3 Immunostimulant (not immunodepressant).
o Single dose of levamisol can be used in ascariasis. Other uses —> A. duodenal (less active against N. americana).
o It causes tonic paralysis (depolarization) by stimulating ganglia.
| A |
Direct antiviral activity |
|
| B |
Indirect antiviral |
|
| C |
Antitumor activity |
|
| D |
It release cytokines |
Ans. is ‘c’ i.e., Antitumor activity
o Imiquimod is a immunomodulatory agent that is effective for topical treatment of Condylomata accuminata and other dermatological conditions.
o It lacks direct antiviral or antiproliferative effects in vitro but rather induces cytokines and chemokines with antiviral and immunomodulating effects.
o Imiquimod shows antiviral activity in animal models after systemic or topical administration.
| A |
Acts as an immunostimulator |
|
| B |
Act as an immunodepressor in high doses |
|
| C |
Single dose is sufficient for the treatment ofpsoriasis |
|
| D |
Acts as antihelminthic by causing depolarization |
Ans. is ‘c’ i.e., Single dose is sufficient for the treatment of psoriasis
Levamisol
o Levamisol is an antihelminthic drug and causes depolarization by stimulating nicotinic receptors.
o Levamisol also has immunomodulatory action :
i) Immunostimulation at low doses
Immunosuppression at high doses
o Uses
i) Colorectal carcinoma
ii) Pediculosis
Psoriasis : slow to act and requires two day therapy per week for prolonged period.
Immunomodulator used in treatment of genital warts is
| A |
ATRA |
|
| B |
Podophyllin |
|
| C |
Imiquimod |
|
| D |
Prednisolone |
C i.e. Imiquimod
