Ketone bodies-Clinical aspects
→ Ketonemia – Ketone body in Blood
→ Ketonuria – Ketone Body in Urine
→ Ketosis = Ketonemia + Ketonuria
→ Ketone Body has protective effect on breakdown of structural proteins
→ They Can cause Metabolic Acidosis with High Anion Gap and Hyperkalemia
→ Hyperkalemia due to inhibition of Na/K Pump due to depletion of Alkali Reserve of the Body
→ Ketogenic Diet – High Fat, Adequate Protein and Low Carbohydrate
→ Use of Ketogenic Diet – Weigh Reduction [Atkin Diet] and Refractory Epilepsy