LITHIUM – PSYCHIATRIC USAGE

LITHIUM – PSYCHIATRIC USAGE


LITHIUM – PSYCHIATRIC USAGE

Indications of lithium in psychiatric disorders:

  • Used for treatment of acute episodes (both mania & depression).
    • Effective treatment for acute mania – Effective serum concentration for acute mania treatment is 1.0-1.5 mEq/ dl.
  • Antimanic efficacy of lithium is more than its antidepressive efficacy.
  • Prophylaxis in bipolar disorder.
  • Maintenance treatment with lithium decreases frequency, severity & duration of manic & depressive episodes in patients with bipolar disorders.
    • Serum concentration required for maintenance treatment is 0.6-1.2 mEq/dl.
  • In schizoaffective disorders.
  • As an adjuvant to antidepressants in major depressive disorder.
  • Other uses:
    • Obsessive-compulsive disorder
    • Aggression
    • Headache (cluster, migraine)
    • Gout
    • Epilepsy
    • Movement disorders
    • Neutropenia
    • Ulcerative colitis.

Exam Important

  • Lithium is used in effective treatment for acute mania & its effective serum concentration is 1.0-1.5 mEq/ dl.
  • Serum lithium concentration required for maintenance treatment is 0.6-1.2 mEq/dl.
  • Lithium is also used for headache (cluster, migraine) & neutropenia.
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