Phosphorus Poisioning

Phosphorus Poisioning


  • Phosphorus is  a protoplasmic  poison  affecting  cellular  oxidation  and causing  anoxic  necorbiosis,  classically  affecting liver.  
  • It increases  fat  deposition  and  inhibits  glycogen  deposition  in  liver.  It is  used  in  fire  works  (Diwali  poisoning)  and as  rat  poison. Lethal dose  is  60-120  mg.
  • Earliar CuSO4 was used as an antidote for phosphorous poisoning.

Phosphorus  occurs  in  two  forms:

White/yellow phosphorus:

  • It  is  white,  and  becomes  yellow  on  exposure  to  air.  
  • It  is  translucent, luminous and  crystalline cylinders.
  • It has garlic like  odor. It is  insoluble  in  water  and  luminous  in  dark. 
  • Its  fumes  show  phosphorescence.

Red phosphorus:

  • It is  reddish  brown,  inert,  odourless  and  tasteless. 
  • It  is  nontoxic  (thus  poisoning  occurs  only  due to white phosphorus.
  • It is  put  on  the  sides  (striking  surface)  of match box  (along  with  powdered  glass).

Acute  poisoning

First stage: (GI  irritation): There  is  nausea,  vomiting,  diarrhea and  garlic odor.  This stage lasts  for  8 hours to  3 days.

Second Stage (Asymptomatic) : This  stage lasts  for  3 days.

Third  Stage:

  • There is liver  and  kidney  damage due  to  absorbed  phosphorus.
  • Initially  liver  is  enlarged  due  to  acute  fatty infiItration.
  • Later  liver  shrinks  due to  necrosis,  i.e.  Acute yellow atrophy.

Chronic  poisoning

  • Toothache  is  the  first  symptom  which  is  associated  with  loosening  of  teeth,  necrosis  of  gums  and osteomyelitis  of  jaw.
  • Therefore  chronic  phosphorus poisoning  is  also  known  as  Phossy  jaw or  glass  jaw.

Postmortem appearance

  • There is  garlic odor.  viscera  and  stool  glow in  dark  (due  to  luminosity).
  • To preserve  luminosity,  viscera  are  preserved  in  saturated  saline solution  Rectified  spirit  is  not  used  as it  causes loss  of Iuminosity.

Exam Important

  • Acute yellow atrophy.
  • liver  and  kidney  damage
  • Phossy  jaw or  glass  jaw.
  • There is  garlic odor.  viscera  and  stool  glow in  dark  (due  to  luminosity)
Don’t Forget to Solve all the previous Year Question asked on Phosphorus Poisioning

Module Below Start Quiz

This site uses Akismet to reduce spam. Learn how your comment data is processed.

%d bloggers like this:
Malcare WordPress Security