Question
Benralizumab is a monoclonal antibody that targets which of the following cytokines or receptors?
| A. |
IL-4
|
| B. |
IL-5
|
| C. |
TNF-α
|
| D. |
IgE
|
Show Answer
|
Correct Answer � B
Explanation
|
|
– Benralizumab is a monoclonal antibody targeting IL-5Rα on eosinophils & basophils.
– It induces antibody-dependent cell-mediated cytotoxicity (ADCC) → eosinophil apoptosis.
– Used for severe eosinophilic asthma, esp. in patients not controlled by inhaled corticosteroids & long-acting beta agonists.
– IL-5 is crucial for eosinophil growth, differentiation, & survival.
Incorrect Options:
– A. IL-4: Targeted by dupilumab (asthma, atopic dermatitis).
– C. TNF-α: Targeted by infliximab, etanercept, adalimumab (autoimmune diseases).
– D. IgE: Targeted by omalizumab (allergic asthma).
