Question
A 58-year-old male with history of multiple sexual partners presents with anorexia and jaundice. Biopsy shows ground glass opacity. What is the most probable diagnosis?
| A. |
Hepatitis B
|
| B. |
Hepatitis C
|
| C. |
Hepatitis A
|
| D. |
Hepatitis D
|
Show Answer
|
Correct Answer � A
Explanation
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|
– Ground glass hepatocytes are characteristic of chronic Hepatitis B infection.
– This appearance results from Hepatitis B surface antigen (HBsAg) accumulation n hepatocyte endoplasmic reticulum.
– Transmission is sexual, parenteral, or vertical.
– Symptoms: anorexia, fatigue → jaundice.
– May progress to cirrhosis & hepatocellular carcinoma.
Reasons to Rule Out Other Options:
Option B: Hepatitis C
– Transmission primarily through blood (e.g., IV drug use).
– Histology: lymphoid aggregates & steatosis; no ground glass hepatocytes.
Option C: Hepatitis A
– Spread via fecal-oral route, often in contaminated food/water.
– Leads to acute, self-limiting hepatitis; not chronic.
Option D: Hepatitis D
– Requires co-infection with Hepatitis B for replication.
– Ground glass hepatocytes result from HBV, not HDV alone.
