MCQ – 136644

A histological section is given below. Identify the marked cells.

https://medicoapps.org/wp-content/uploads/2025/10/20251010051042_0.jpg

Correct Answer � C Explanation

• The marked cells are large, flask-shaped neurons located in a distinct single layer between a densely cellular inner layer and a pale outer layer — this is classic for Purkinje cells in the cerebellar cortex.

• Their dendrites project upward into the molecular layer, and axons pass downward into the deep cerebellar nuclei.

Histological Layers of the Cerebellar Cortex:

1. Molecular Layer (Outer):

   • Sparse cells: stellate and basket cells

   • Contains dendritic trees of Purkinje cells and parallel fibers from granule cells

2. Purkinje Cell Layer (Middle):

   • Single row of large Purkinje cells

   • Only output neurons of the cerebellar cortex (inhibitory: GABAergic)

3. Granular Layer (Inner):

   • Packed with small granule cells

   • Axons ascend to molecular layer → bifurcate into parallel fibers