Question
Which of the following immunosuppressive agents have a side effect of osteoporosis?
| A. |
Cyclophosphamide
|
| B. |
Methotrexate
|
| C. |
Glucocorticoids
|
| D. |
Mycophenolate mofetil
|
Show Answer
|
Correct Answer � C
Explanation
|
|
| Side effects of common Immuno-Suppressants are given below: |
| Cyclophosphamide: Leucopenia or neutropenia, infections (usually respiratory and urinary tract), infertility, cancer (especially bladder cancer and leukemia), hemorrhagic cystitis, alopecia, and amenorrhoea |
| Glucocorticoids: Osteoporosis, candida infection (oral and vaginal), other infections, weight gain, hyperglycemia or diabetes, hypertension, cushingoid appearance, skin atrophy, and cataract |
| Azathioprine: Nausea, leucopenia or neutropenia, infection, hypersensitivity, cancer, alopecia, cholestasis, and thrombocytopenia |
| Methotrexate: Nausea, oral ulcers, liver dysfunction, infection, hypertension, leucopenia |
|
Mycophenolate mofetil: infection, leucopenia, gastrointestinal tract manifestations, anemia, thrombocytopenia
|
| Rituximab: Infections (encephalitis is particularly dangerous), cancer, anemia, neutropenia, thrombocytopenia, hypogammaglobulinemia |
