Question
Congenital lactic acidosis may occur due to the defect in:
| A. |
Pyruvate decarboxylase
|
| B. |
PDH complex
|
| C. |
Transketolase
|
| D. |
α-ketoglutarate dehydrogenase
|
Show Answer
|
Correct Answer � B
Explanation
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|
Ans.B. PDH complex
Congenital lactic acidosis is a rare form of lactic acidosis.
Symptoms of congenital lactic acidosis develop within the first hours or days of life and may include loss of muscle tone (hypotonia), lethargy, vomiting and tachypnea.
Eventually, the condition may progress to cause developmental delay, mental retardation, motor abnormalities, behavioral issues, abnormalities of the face and head and, ultimately, multi-organ failure.
