Question
Desmopressin is preferred over vasopressin because desmopressin –
| A. |
More potent
|
| B. |
More selective for Vireceptor
|
| C. |
Has little vasoconstrictor activity
|
| D. |
a and c
|
Show Answer
|
Correct Answer » D
Explanation
|
|
Desmopressin
Mechanism
- Selective V2 receptor agonist
Actions
- Increases water reabsorption in collecting ducts
- Increases release of factor VIII and von Willebrand factor
Uses
- Central diabetes insipidus
- Nocturnal enuresis
- Mild hemophilia A
- von Willebrand disease type 1
Advantages over Vasopressin
- Longer duration of action
- More potent antidiuretic effect
- Minimal vasoconstriction
- Fewer cardiovascular side effects
Receptor Functions
V1 receptor
- Vasoconstriction
- Smooth muscle contraction
V2 receptor
- Water reabsorption in kidney
- Increased factor VIII and vWF release
