Question
Zollinger-Ellison syndrome is true, except:
| A. |
Surgery is to be done
|
| B. |
Exocrine tumor
|
| C. |
Endocrine disorder
|
| D. |
Secretory diarrhea seen
|
Show Answer
|
Correct Answer » B
Explanation
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|
Definition: Syndrome caused by gastrin-secreting neuroendocrine tumor (gastrinoma)
Common sites:
- Duodenum (most common)
- Pancreas
Pathophysiology
- Excess gastrin → increased gastric acid secretion
- Leads to multiple, recurrent peptic ulcers
Clinical Features
- Severe peptic ulcer disease (often multiple, refractory)
- Ulcers in atypical locations (e.g., jejunum)
- Secretory diarrhea
- Gastroesophageal reflux disease (GERD: Gastroesophageal Reflux Disease)
Diagnosis
- Elevated fasting serum gastrin
- Secretin stimulation test (paradoxical rise in gastrin)
- Imaging to localize tumor
Associations
- Multiple Endocrine Neoplasia type 1 (MEN1: Multiple Endocrine Neoplasia type 1)
Management
- Proton pump inhibitors (PPIs) for acid suppression
- Surgical resection if localized
- Somatostatin analogs in metastatic disease
