Question
Which of the following is NOT a recognized classic paraneoplastic manifestation of renal cell carcinoma (RCC)?
| A. |
Polycythemia
|
| B. |
Hypercalcemia
|
| C. |
Cushing syndrome
|
| D. |
Myasthenia gravis
|
Show Answer
|
Correct Answer » D
Explanation
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|
A. Polycythemia — Associated
- RCC may produce erythropoietin.
- Increased erythropoietin causes secondary polycythemia.
- This is a classic paraneoplastic manifestation of RCC.
B. Hypercalcemia — Associated
- RCC can produce parathyroid hormone-related peptide (PTHrP).
- This may cause paraneoplastic hypercalcemia.
C. Cushing syndrome — Associated
- Rarely, RCC can produce adrenocorticotropic hormone (ACTH) or an ACTH-like substance.
- This can produce Cushing syndrome.
D. Myasthenia gravis — NOT associated
- Myasthenia gravis is not a classic paraneoplastic manifestation of RCC.
- It is classically associated with thymoma.
