Question
Ergot derivatives are used in all of the following except :
| A. |
Induction of Uterine contraction
|
| B. |
Treatment of Vasoconstrictive disorders
|
| C. |
Treatment of Migraine
|
| D. |
Treatment of Galactorrhoea
|
Show Answer
|
Correct Answer » B
Explanation
|
|
Ans. B: Vasoconstrictive Disorders
Clinical Reasoning for the Correct Answer:– Ergot derivatives (e.g., ergotamine, ergonovine, bromocriptine) exhibit vasoconstrictive action. – They are contraindicated in vasoconstrictive disorders (e.g., peripheral vascular disease, Raynaud’s phenomenon). – Use in such conditions may precipitate severe ischemic complications.
Why Option A is Incorrect:
– Used for uterine contraction (e.g., ergometrine) in postpartum hemorrhage due to their potent oxytocic action.
– They stimulate smooth muscle contraction in the uterus.
Why Option C is Incorrect:
– Ergotamine is commonly used to treat acute migraine attacks.
– Acts via serotonin (5-HT) receptor agonism leading to cranial vasoconstriction.
Why Option D is Incorrect:
– Bromocriptine, an ergot derivative, is used in galactorrhoea and hyperprolactinemia.
– It works as a dopamine agonist, reducing prolactin secretion.
