Question
Following all are antigens for antiphospholipid antibody except ‑
| A. |
Prothrombin
|
| B. |
Erythrocyte membrane
|
| C. |
Phospholipid
|
| D. |
Beta 2 glycoprotein
|
Show Answer
|
Correct Answer � B
Explanation
|
|
Ans. is ‘b’ i.e., Erythrocyte membrane
Antiphospholipid syndrome
- Antiphospholipid syndrome develops in patients expressing antibodies to anionic phospholip. i.e., antiphospholipid antibody or lupus anticoagulant.
- These antibodies not only act against phospholipid, as it was believed, but also against epitopes of plasma proteins.
- A variety of protein have been implicated; 2-glycoprotein particularly important, i.e., antiphospholipid antibody is directed against the phospholipid – 2-glycoprotein complex.
- Other proteins are prothrombin, protein S, protein C, annexin V.
Three antibody are particularly important :
- Antiphospholipid (anti Cardiolipin)
- Anti-2-glycoprotein (i.e., against 2-glycoprotein component of phosphilipid-2-glycoprotein complex).
- A nti-prothrombin
