Question
In Sickle Cell Anaemia defect is in which chain:
| A. |
Alphachain
|
| B. |
Beta chain
|
| C. |
Both the chains
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| D. |
None of these
|
Show Answer
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Correct Answer � B
Explanation
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|
Beta chain
The mutation in the HBB gene in sickle cell anemia changes one of the amino acids, the building blocks of proteins, in the beta chain of hemoglobin. This defect causes the hemoglobin protein to stick together and form stiff fibers. These fibers distort the shape of the red blood cells and make them more fragile.
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