Question
A patient ,who is frequently exposed to the sunlight presented with the following lesions.Regarding this condition,which of the following statement is false?
| A. |
Long term UV light exposure is implicated as the cause
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| B. |
May progress to Basal Cell Carcinoma
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| C. |
Most common lesion with malignant potential to arise on the skin.
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| D. |
Characterised by Dysplasia
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Show Answer
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Correct Answer � B
Explanation
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Ans:B.)May progress to Basal Cell Carcinoma
The patient in question is suffering from Actinic Keratosis.
ACTINIC KERATOSIS
- lt is a UV light-induced lesion of the skin that may progress to invasive squamous cell carcinoma.
- Most common lesion with malignant potential to arise on the skin.
- Actinic keratosis arise on fair-skinned people in areas of long-term sun exposure, such as the face, ears, bald scalp, forearms, and backs of the hands.
- They may occur on any area that is repeatedly exposed to the sun, such as the back, the chest, and the legs.
- Long term UV light exposure is implicated as the cause from both epidemiologic observations and molecular analysis of tumor cells.
- Clinically, actinic keratosis range from barely perceptible rough spots of skin to elevated, hyperkeratotic plaques several centimeters in diameter.
- Most often, they appear as multiple discrete, flat or elevated, keratotic lesions.
- Lesions typically have an erythematous base covered by scale (hyperkeratosis).
- They are usually 3-10 mm in diameter and gradually enlarge into broader, more elevated lesions.
- Over time, actinic keratosis may develop into invasive squamous cells.
- A skin biopsy is indicated to confirm the diagnosis and to rule out invasive squamous cell carcinoma:
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Actinic keratosis is characterized by dysplasia and architectural disorder of the epidermis, as follows :
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Abnormal keratinocytes of the basal layer that are variable in size and shape
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Altered cellular polarity
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Nuclear atypia
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Hyperkeratosis and parakeratosis of the epidermis
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Irregular acanthosis may be present
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