Question
The Space of Disse is found in which of the following organs?
| A. |
Spleen
|
| B. |
Lymph node
|
| C. |
Liver
|
| D. |
Bone
|
Show Answer
|
Correct Answer � C
Explanation
|
|
Space of Disse:
– Found in the liver, located between sinusoidal endothelium & hepatocytes.
Function:
– Facilitates exchange of nutrients, oxygen & waste between hepatocytes & blood.
– Contains hepatic stellate (Ito) cells for vitamin A storage, liver regeneration, & fibrosis.
Clinical Relevance:
– In liver disease (e.g., cirrhosis), fibrosis of Space of Disse impedes exchange, contributing to dysfunction.
