Question
All of these are G2 phase blockers except:
| A. |
Etoposide
|
| B. |
Topotecan
|
| C. |
Paclitaxel
|
| D. |
Daunorubicin
|
Show Answer
|
Correct Answer � C
Explanation
|
|
Ans: C. Paclitaxel
Paclitaxel:
- Taxane, which acts by disrupting the cell’s microtubule function by stabilizing microtubule formation.
- Acts on the M-phase of cell division.
- Binds specifically to the P-tubulin subunit of microtubules and antagonizes the disassembly of this key cytoskeletal protein, with the result that bundles of microtubules and aberrant structures derived from microtubules appear in the mitotic phase of the cell cycle.
- Arrest in mitosis follows.
