Question
A 6 month old child presented with diarrhea for few days. He had dermatitic lesions on his hands and feet. Scalp hair was comparatively less. Deficiency of zinc was suspected. TRUE about acrodermatitis enteropathica is:
| A. |
Autosomal dominant inheritance
|
| B. |
X-linked recessive inheritance
|
| C. |
Zinc therapy produces only partial improvement
|
| D. |
Autosomal recessive inheritance
|
Show Answer
|
Correct Answer » D
Explanation
|
|
- Acrodermatitis enteropathica is a hereditary disorder of impaired zinc absorption.
- It is caused by mutation in the SLC39A4 gene.
- Inheritance pattern is autosomal recessive.
- Classical features include:
- Diarrhea
- Acral and periorificial dermatitis
- Alopecia/sparse hair
Reasons to Rule Out Other Options
A. Autosomal dominant inheritance
- Incorrect inheritance pattern
B. X-linked recessive inheritance
C. Zinc therapy produces only partial improvement
- Zinc supplementation usually causes dramatic clinical improvement
