Question
A pregnant woman in first trimester has four fold rise in IgG against toxoplasmosis. it indicates ‑
| A. |
Protective antibodies
|
| B. |
Acute infection
|
| C. |
Chronic infection
|
| D. |
None of the above
|
Show Answer
|
Correct Answer » B
Explanation
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|
- Toxoplasmosis is caused by the protozoan Toxoplasma gondii.
- During pregnancy, primary maternal infection, especially in the first trimester, is associated with the highest risk of severe fetal disease.
- A fourfold rise in IgG antibody titer between acute and convalescent serum samples is evidence of recent (acute) infection.
Explanation of the Correct Answer
Option B: Acute (recent) Toxoplasma gondii infection
- Correct.
- A fourfold or greater rise in IgG antibody titer on paired sera confirms recent active infection.
- Acute infection during pregnancy requires prompt evaluation and treatment to reduce the risk of congenital toxoplasmosis.
Why Other Options are Incorrect
Option A: Protective antibodies
- Presence of stable IgG antibodies without a significant rise indicates previous exposure and immunity.
- A fourfold rise indicates active infection rather than simple immunity.
Option C: Chronic infection
- Chronic infection is characterized by persistent IgG positivity with stable titers.
- There is no significant rise in antibody levels.
