Question
Drug not used commonly for menorrhagea ‑
| A. |
Methergin |
| B. |
Clomiphene |
| C. |
GnRH |
| D. |
NSAIDS |
|
Correct Answer » B Explanation |
 |
– Menorrhagia = excessive menstrual bleeding.
– Management drugs work by:
– Reducing endometrial proliferation
– Decreasing prostaglandins
– Suppressing ovarian hormones
B. Clomiphene citrate
– A selective estrogen receptor modulator (SERM).
– Blocks estrogen receptors in hypothalamus → ↑ gonadotropins (FSH, LH).
– Used for ovulation induction in infertility.
– Has no role in treating menorrhagia.
Explanation of Other Options:
A. Methylergometrine (Methergine)
– Ergot alkaloid causing sustained uterine contractions.
– Used in postpartum hemorrhage & post-abortal bleeding.
– Controls acute uterine bleeding but not chronic menorrhagia.
C. Gonadotropin-releasing hormone (GnRH) analogs
– Induce hypoestrogenic state → endometrial atrophy.
– Used for severe menorrhagia, fibroids, pre-op.
– Effective but limited by side effects (bone loss, hot flashes).
D. Nonsteroidal anti-inflammatory drugs (NSAIDs)
– Reduce prostaglandins → ↓ uterine blood flow.
– Common first-line therapy for mild to moderate menorrhagia.
