Question
Proto-oncogene is converted into an oncogene by a point mutation in which of the following?
| A. |
RAS
|
| B. |
MYC
|
| C. |
HER2/neu
|
| D. |
BCL-2
|
Show Answer
|
Correct Answer » A
Explanation
|
|
Proto-oncogenes become oncogenes through different mechanisms:
- Point mutation
- Gene amplification
- Chromosomal translocation
- Promoter/enhancer insertion
RAS gene
-
- Classic example of activation by point mutation
- Mutation leads to:
- Continuous activation of GTP-binding protein
- Uncontrolled cell proliferation
Explanation of Other Options
- B. MYC
- Activated by chromosomal translocation
- Example: t(8;14) in Burkitt lymphoma
- C. HER2/neu
- Activated by gene amplification
- Seen in breast cancer
- D. BCL-2
- Activated by translocation
- Example: t(14;18) in follicular lymphoma
