Question
Mechanism of action of toxins produced by the Bacterium shown in figure
| A. |
Increase in cAMP
|
| B. |
Increase in cGMP
|
| C. |
ADP-ribosylation of EF-2
|
| D. |
ADP-ribosylation of Gs protein
|
Show Answer
|
Correct Answer � C
Explanation
|
|
Answer- C. ADP-ribosylation of EF-2
- Bacterial ADP-ribosylating exotoxins (bAREs) covalently transfer an ADP-Ribose moiety of NAD+ to target proteins of infected eukaryotes, to yield nicotinamide and a free hydrogen ion.
- Elongation factors are targets for the toxins of some pathogens. Corynebacterium diphtheriae produces its toxin, which alters protein function in the host by inactivating elongation factor (EF-2). This results in the pathology and symptoms associated with Diphtheria
