Question
A 35-year-old nulliparous woman complains that her breasts are swollen and nodular upon palpation. A mammogram discloses the foci of calcification in both breasts. A breast biopsy is shown in the picture What is the appropriate diagnosis?
| A. |
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| B. |
Fibroadenoma
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| C. |
Fibrocystic change
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| D. |
Granulomatous mastitis
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Show Answer
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Correct Answer � C
Explanation
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Fibrocystic change of the breast refers to a constellation of morphologic features characterized by
(1) cystic dilation of terminal ducts
(2) The relative increase in the fibrous stroma, and
(3) The variable proliferation of terminal duct epithelial elements.
- Some of the florid manifestations appear to be indicators for an increased risk for breast cancer. Such lesions are designated proliferative fibrocystic change.
- Forms of fibrocystic change that do not carry an increased risk for the development of cancer, termed non- proliferative fibrocystic change, are far more prevalent.
- Ductal carcinoma in situ features malignant epithelial cells that have not penetrated the basement membrane.
- Intraductal papilloma occurs in the subareolar lactiferous ducts.
- None of the remaining incorrect choices feature cystic duct dilation.
