Ans. B. Hyperparathyroidism
A 45-year-old woman having salt and pepper appearance in the skull with dentine defects and loss of lamina dura most likely suggests hyperparathyroidism.
Radiological features of hyperparathyroidism:
Classical and pathognomonic features of hyperparathyroidism is subperiosteal cortical resorption of middle phalanges, seen especially in the second and third fingers. This feature can also be visualized in the lateral end of the clavicle and symphysis pubis.
Loss of lamina Dura (thin cortical bone of tooth socket surrounding teeth is seen as a thin white line).
Generalized osteopenia, thinning of cortice and indistinct bony trabeculae.
Expansile lytic lesion, otherwise known as brown’s tumor generally affecting maxilla/mandible.
Salt and pepper appearance of the skull is seen.