Question
A routine lipid profile in a 32-year-old woman reveals hypertriglyceridemia. Which of the following is a recognized secondary cause of hypertriglyceridemia that should be evaluated?
| A. |
Hypothyroidism
|
| B. |
Hyperthyroidism
|
| C. |
Inhaled β₂-adrenergic agonists (β₂-agonists)
|
| D. |
Hyperparathyroidism
|
Show Answer
|
Correct Answer » A
Explanation
|
|
Before diagnosing primary (familial) hypertriglyceridemia, secondary causes should be excluded. Hypothyroidism is a well-recognized secondary cause because reduced thyroid hormone levels decrease lipoprotein lipase activity and impair lipid metabolism, leading to elevated triglyceride and cholesterol levels.
Why the Other Options Are Incorrect
B. Hyperthyroidism
- Hyperthyroidism generally lowers serum cholesterol and triglyceride levels due to increased lipid metabolism.
- It is not a recognized cause of hypertriglyceridemia.
C. Inhaled β₂-adrenergic agonists (β₂-agonists)
- Inhaled β₂-agonists are not a routine secondary cause of hypertriglyceridemia.
- They are not routinely evaluated during the work-up of elevated triglycerides.
D. Hyperparathyroidism
- Hyperparathyroidism is not associated with secondary hypertriglyceridemia.
