Question
A 69-year-old woman develops dark, velvety pigmentation in her axillae. She has noticed 10 lb weight loss over the past 3 months with heartburn and early satiety. She notices no other symptoms. Which of the following conditions should she be studied for?
| A. |
a visceral carcinoma
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| B. |
lymphoma
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| C. |
diabetes mellitus
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| D. |
sarcoidosis
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Show Answer
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Correct Answer � A
Explanation
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Ans. (A)
Patients with acanthosis nigricans should be studied for visceral carcinoma. There are hereditary, drug-induced, and benign forms of acanthosis nigricans as well. Given this patient’s symptoms, a gastric malignancy should be ruled out. Diabetics get a benign form of
the disorder. Other dermatoses associated with malignancy include dermatomyositis, flushing, acquired ichthyosis, and thrombophlebitis migrans.
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