A 64-year-old woman develops severe diarrhea 2 weeks after finishing antibiotics for pneumonia. She has also noticed a decrease in the risk of urine output despite drinking lots of fluids. On examination, she has a postural drop in her blood pressure, the JVP is low, and the abdomen is soft but diffusely tender. Despite giving 4 L of normal saline, her urine output remains low. The urinalysis is positive for heme-granular casts and the urine sodium is 42 mEq/L. Which of the following medications should be held during the recovery phase of this woman’s ARF?
Although all drugs should be reassessed at this time, and if appropriate, the dosage adjusted, drugs with known neurotoxicities, such as ACE inhibitors and NSAIDs, should be stopped.