Mixed connective tissue disorder
Antinuclear antibodies are present in many disorders, such as SLE, scleroderma, Sjögren’s syndrome, and rheumatoid arthritis, among others.
Clinically, their repeated absence goes against the diagnosis of SLE. However, in other disorders, they have a limited diagnostic role.
Features of dry eyes and dry mouth in a 60-year-old female suggest the diagnosis of Sjögren’s syndrome.
Sjogren’s syndrome can be primary or secondary.
Secondary Sjögren’s syndrome is associated with various disorders such as rheumatoid arthritis, SLE, mixed connective tissue disorder, and others.
However, no additional clinical features are provided to consider an alternate diagnosis.
Behcet’s disease involves oral and genital ulcers with uveitis.