Sickle cell disease; Beta chain
Beta thalassemia intermedia ; Beta chain
G6PD deficiency; Glucose-6-phosphatase enzyme
Hereditary spherocytosis; Ankyrin
Ans. D. Hereditary spherocytosis; Ankyrin
Peripheral smear shows round cells with absent central pallor suggestive of a spherocyte.HS is an autosomal dominant condition presenting with anemia, jaundice, and splenomegaly needing transfusions. The most common underlying protein defect is ankyrin.