Question
Cytogenetic studies in a 40-year-old woman with follicular lymphoma demonstrate a t(14;18) chromosomal translocation involving the bcl-2 gene. Constitutive expression of the protein encoded by the bcl-2 gene inhibits which of the following processes in this patient’s transformed lymphocytes?
| A. |
Apoptosis
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| B. |
DNA excision repair
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| C. |
G1-to-S cell cycle progression
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| D. |
Oxidative phosphorylation
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Show Answer
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Correct Answer � A
Explanation
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Correct answer : a Apoptosis
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Many human cancers show abnormalities in the control of apoptosis.
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For example, follicular B-cell lymphomas display a characteristic chromosomal translocation in which the bcl-2 gene is brought under the transcriptional control of the immunoglobulin light-chain gene promoter, thereby causing overexpression of bcl-2.
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As a result of the antiapoptotic properties of bcl-2, the neoplastic clone accumulates in lymph nodes. Since its demonstration in follicular lymphomas, bcl-2 expression has been observed in a variety of other human cancers.
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None of the other choices describes the function of bcl-2.
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