|B.||DNA excision repair|
G1-to-S cell cycle progression
Correct answer : a Apoptosis
Many human cancers show abnormalities in the control of apoptosis.
For example, follicular B-cell lymphomas display a characteristic chromosomal translocation in which the bcl-2 gene is brought under the transcriptional control of the immunoglobulin light-chain gene promoter, thereby causing overexpression of bcl-2.
As a result of the antiapoptotic properties of bcl-2, the neoplastic clone accumulates in lymph nodes. Since its demonstration in follicular lymphomas, bcl-2 expression has been observed in a variety of other human cancers.
None of the other choices describes the function of bcl-2.