Question
A 25-year-old woman develops a sore, red, hot, swollen left knee. She has no history of trauma and no familial history of joint disease. Fluid aspirated from the joint space shows an abundance of segmented neutrophils. Transendothelial migration of acute inflammatory cells into this patient’s joint space was mediated primarily by which of the following families of proteins?
| A. |
Entactins
|
| B. |
Fibrillins
|
| C. |
Fibronectins
|
| D. |
Integrins
|
Show Answer
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Correct Answer � D
Explanation
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|
Correct answer :d Integrins
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Chemokines and other proinflammatory molecules activate a family of cell adhesion molecules, namely the integrins.
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Molecules in this family participate in cell-cell and cell-substrate adhesions and cell signaling.
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Integrins are involved in leukocyte recruitment to sites of injury in acute inflammation. The other choices are extracellular matrix molecules that maintain tissue architecture and facilitate wound healing.
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