Interaction with HbF
Ans. D. Oxygen unloading
Explanation:Hemoglobin S (HbS) aggregates in the deoxygenated state. HbS polymers form fibrous strands that reduce red blood cell membrane flexibility and promote sickling. Sickling occurs under all conditions associated with anoxia including low pH and high 2,3-DPG. These inflexible erythrocytes predispose to microvascular occlusion and microinfarction.