Chylomicron secretion by the intestine
Chylomicron remnant uptake by liver cells
LDL particle uptake by extrahepatic cells
Lipoprotein lipase activation
Ans. B. Chylomicron remnant uptake by liver cells
Explanation: Familial dysbetalipoproteinemia (type Ill hyperlipoproteinemia) is characterized clinically by xanthomas and premature coronary and peripheral vascular disease. The primary defects in familial dysbetalipoproteinemia are in ApoE3 and ApoE4, apolipoproteins found on chylomicrons and VLDL that are responsible for binding hepatic apolipoprotein receptors. Without ApoE3 and ApoE4, the liver cannot efficiently remove chylomicrons and VLDL remnants from the circulation, causing their accumulation in the serum and resultant elevations in cholesterol and triglyceride levels.