MCQ – 89218

Question

A 6-year-old Caucasian boy is brought to the pediatrician’s office by his mother. She tells you that since he’s been born, he has had multiple bouts of sinusitis. The mother states that his previous pediatrician performed a “sweat test” to help determine the cause of his frequent infections, but that the test came back normal. The boy has no other medical problems. Suspicious of an underlying etiology, his current physician orders nasal transepithelial potential difference measurements. The results show a baseline potential difference that is more negative than normal. Which of the following processes most likely underlies this finding:

A. Increased chloride secretion

B.

Increased sodium absorption

C.

Intracellular potassium depletion

D.

High mucus water content

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