|A.||Pulmonary involvement attributes majorly to the morbidity and mortality|
An autosomal recessive inheritance
Most common mutation -F508del
Meconium plug syndrome could be the only clue at neonatal period
Ans. D.Meconium plug syndrome could be the only clue at neonatal period
Cystic fibrosis can present with delayed passage of meconium in around 20% of cases because of meconium ileus, which happens because of inspissated meconium (pancreatic insufficiency and defective biliary and gastrointestinal secretions)
This is different from a relatively common called meconium plug syndrome. This primarily happens because of a physiological defect/delay in the large intestinal motility. This condition accounts for the most common cause of delayed passage of meconium in a neonate.