Question
A 3-year boy with a history of recurrent pneumonia and faltering growth is subjected to a sweat chloride test, which comes back positive with levels more than 80 mmol/L on two occasions. Which of the following statements about this condition is incorrect:
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Pulmonary involvement attributes majorly to the morbidity and mortality
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| B. |
An autosomal recessive inheritance
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| C. |
Most common mutation -F508del
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| D. |
Meconium plug syndrome could be the only clue at neonatal period
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Show Answer
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Correct Answer � D
Explanation
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Ans. D.Meconium plug syndrome could be the only clue at neonatal period
Cystic fibrosis can present with delayed passage of meconium in around 20% of cases because of meconium ileus, which happens because of inspissated meconium (pancreatic insufficiency and defective biliary and gastrointestinal secretions)
This is different from a relatively common called meconium plug syndrome. This primarily happens because of a physiological defect/delay in the large intestinal motility. This condition accounts for the most common cause of delayed passage of meconium in a neonate.
