Question
Which of the following drugs worsens Myasthenia gravis?
| A. |
Meropenem
|
| B. |
Alpha blocker
|
| C. |
Lignocaine
|
| D. |
Penicillin
|
Show Answer
|
Correct Answer � C
Explanation
|
|
Ans. C Lignocaine
Myasthenia gravis (MG):
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Myasthenia gravis (MG) is an autoimmune disease causing muscle weakness due to impaired transmission at the neuromuscular junction.
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MG or a MG-like condition may be triggered or exacerbated by several drugs used for treatment of other diseases.
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rugs may interfere with the neuromuscular transmission through several mechanisms, either by affecting pre- or postsynaptic ion channels or by affecting acetylcholinesterase.
Drugs Exacerbating Myasthenia Gravis:
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Aminoglycosides
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Macrolides
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Magnesium
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Curare
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Local anesthetics
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Quinine & Quinidine
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Beta Blockers
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Botulinum Toxin
-
Penicillamine
