Question
Regarding the Kayser-Fleischer ring, which of the following is true?
| A. |
Disappears with Desferrioxamine
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| B. |
Starts first in superior and inferior cornea
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| C. |
Seen in all cases of hepatic involvement
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| D. |
Seen in all cases of brain involvement of Wilson’s disease
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Show Answer
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Correct Answer � B
Explanation
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Kayser-Fleischer (K-F) ring is a golden-brown ring seen at the periphery of the cornea due to copper deposition in Descemet’s membrane, typically in Wilson’s disease.
It begins in the superior and inferior parts of the cornea and gradually progresses circumferentially.
Other important points:
- The K-F ring disappears with penicillamine or zinc therapy, not with Desferrioxamine (used for iron overload).
- It is not seen in all cases of hepatic or brain involvement in Wilson’s disease, though it is more common in neurologic cases.
Other causes of KF rings are cholestasis (obstruction of the bile ducts), primary biliary cirrhosis and “cryptogenic” cirrhosis (cirrhosis in which no cause can be identified).
